Neurobiology of Disease Bone Marrow Transplantation Confers Modest Benefits in Mouse Models of Huntington’s Disease

Wanda Kwan,1,2 Anna Magnusson,7 Austin Chou,3 Anthony Adame,8 Monica J. Carson,9 Shinichi Kohsaka,10 Eliezer Masliah,8 Thomas Möller,11 Richard Ransohoff,12 Sarah J. Tabrizi,13 Maria Björkqvist,7 and Paul J. Muchowski1,2,3,4,5,6 1Biomedical Sciences Program, 2Gladstone Institute of Neurological Disease, 3Neuroscience Program, 4The Taube-Koret Center for Huntington’s Disease Research, and Departments of 5Biochemistry and Biophysics and 6Neurology, University of California, San Francisco, San Francisco, California 94158, 7Brain Disease Biomarker Unit, Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, S-221 84 Lund, Sweden, 8Department of Neurosciences, University of California, San Diego, La Jolla, California, 92093, 9Division of Biomedical Sciences, Center for Glial-Neuronal Interactions, University of California, Riverside, California 92521, 10Department of Neurochemistry, National Institute of Neuroscience, Kodaira, Tokyo 187-8502, Japan, 11Department of Neurology, School of Medicine, University of Washington, Seattle, Washington 98195, 12Neuroinflammation Research Center, Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, and 13Department of Neurodegenerative Disease, UCL Institute of Neurology, London WC1N 3BG, United Kingdom